Oxalyl chloride → 2,6-Difluoro-4-methoxybenzoyl chloride

HRID 466489Notes

Reaction equation

HRID 466489 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[F:7][C:8]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[C:13]([F:19])C=1C(O)=O>C1C=CC=CC=1.CN(C=O)C>[F:7][C:8]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[C:13]([F:19])[C:1]=1[C:2]([Cl:4])=[O:3]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 27782282,6-Difluoro-4-methoxybenzoic acid

Product 1

HCID 27787682,6-Difluoro-4-methoxybenzoyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 241BenzeneSolvent2×

Procedure

A solution of oxalyl chloride (36.5 g, 0.29 mol) in dry benzene (50 ml) was added dropwise to a stirred solution of compound 24 (25.5 g, 0.14 mol) and dry DMF (40 drops) in dry benzene (500 ml) at room temperature. The mixture was stirred at room temperature overnight and the excess of oxalyl chloride and benzene were removed in vacuo.

Workup

  1. customthe excess of oxalyl chloride and benzene were removed in vacuo

Sources & evidence

ORD record
ord-4accdac8a97c4df19fd1dc2bd631cea3
Source dataset
uspto-grants-1992_10
Patent number
US05156763

Reaction notes

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