反应详情

A mixture of 3.2 parts of 3-chloro-6-(methylsulfonyl)pyridazine, 3 parts of 1-(3-methylphenyl)piperazine, 2 parts of N,N-diethylethanamine and 180 parts of benzene was stirred for 24 hours at reflux. The reaction mixture was evaporated. Water was added to the residue. The precipitated product was filtered off, washed with water and dissolved in trichloromethane. The solution was dried, filtered and evaporated. The residue was crystallized from methanol. The product was filtered off and dried, yielding 5 parts (89%) of 3-[4-(3-methylphenyl)-1-piperazinyl]-6-(methylsulfonyl)pyridazine; mp. 201° C. (compound 209).

1. temperatureat reflux
2. customThe reaction mixture was evaporated
3. additionWater was added to the residue
4. filtrationThe precipitated product was filtered off
5. washwashed with water
6. dissolutiondissolved in trichloromethane
7. customThe solution was dried
8. filtrationfiltered
9. customevaporated
10. customThe residue was crystallized from methanol
11. filtrationThe product was filtered off
12. customdried