HRID466675

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

结构：BrCc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1

HCID10053461

5-[4'-(Bromomethyl)[1,1'-biphenyl]-2-yl]-1-(triphenylmethyl)-1H-tetrazole

C33H25BrN4

HCID15020852

7-Methyl-2-propyl-1H-imidazo[4,5-b]pyridine

C10H13N3

PRODUCTS

生成物

结构：CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1

HCID15020853

未命名化合物

PROCEDURE

实验过程

3-[2'-(N-triphenylmethyltetrazol-5-yl)biphen-4-yl]methyl-7-methyl-2-propyl-3H-imidazo[4,5-b]pyridine was prepared according to the procedure described in Example 7, Part A from 2-propyl-7-methylimidazo[4,5-b]pyridine (991 mg, 5.66 mmol), N-triphenylmethyl-5-(4'-bromomethylbiphen-2-yl)tetrazole (3.0 g, 5.39 mmol), and NaH (6.47 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-661a284f1f62408f8a8e6a2efc9aa5eb
来源数据集: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05157026
来源说明: uspto-grants-1992_10

反应 SMILES

[CH2:1]([C:4]1[NH:5][C:6]2[C:7]([N:13]=1)=[N:8][CH:9]=[CH:10][C:11]=2[CH3:12])[CH2:2][CH3:3].[C:14]1([C:20]([C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[N:21]2[C:25]([C:26]3[C:31]([C:32]4[CH:37]=[CH:36][C:35]([CH2:38]Br)=[CH:34][CH:33]=4)=[CH:30][CH:29]=[CH:28][CH:27]=3)=[N:24][N:23]=[N:22]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[H-].[Na+]>>[C:46]1([C:20]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)[N:21]2[C:25]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:31]=3[C:32]3[CH:37]=[CH:36][C:35]([CH2:38][N:13]4[C:7]5=[N:8][CH:9]=[CH:10][C:11]([CH3:12])=[C:6]5[N:5]=[C:4]4[CH2:1][CH2:2][CH3:3])=[CH:34][CH:33]=3)=[N:24][N:23]=[N:22]2)[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1