Sodium hydride → 2-Butyl-7-methyl-3-(2'-(N-triphenylmethyltetrazol-5-yl)biphen-4-yl)methyl-3H-imidazo[4,5-b]pyridine

HRID 466678Notes

Reaction equation

HRID 466678 reaction equation
[CH2:1]([C:5]1[NH:6][C:7]2[C:8]([N:14]=1)=[N:9][CH:10]=[CH:11][C:12]=2[CH3:13])[CH2:2][CH2:3][CH3:4].[C:15]1([C:21]([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[N:22]2[C:26]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]3[CH:38]=[CH:37][C:36]([CH2:39]Br)=[CH:35][CH:34]=3)=[N:25][N:24]=[N:23]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[H-].[Na+]>>[CH2:1]([C:5]1[N:14]([CH2:39][C:36]2[CH:35]=[CH:34][C:33]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[C:26]3[N:22]([C:21]([C:47]4[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=4)([C:41]4[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=4)[C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[N:23]=[N:24][N:25]=3)=[CH:38][CH:37]=2)[C:8]2=[N:9][CH:10]=[CH:11][C:12]([CH3:13])=[C:7]2[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 100534615-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazoleHCID 150152652-Butyl-7-methyl-1H-imidazo[4,5-b]pyridine

Product 1

HCID 1317175862-Butyl-7-methyl-3-(2'-(N-triphenylmethyltetrazol-5-yl)biphen-4-yl)methyl-3H-imidazo[4,5-b]pyridine

Procedure

2-Butyl-7-methyl-3-(2'-(N-triphenylmethyltetrazol-5-yl)biphen-4-yl)methyl-3H-imidazo[4,5-b]pyridine was prepared according to the procedure described in Example 7, Part A from 2-butyl-7-methylimidazo[4,5-b]pyridine (28 mg, 0.148 mmol), N-triphenylmethyl-5-(4'-bromomethylbiphenyl-2-yl)tetrazole (62 mg, 0.135 mmol), and NaH (0.296 mmol).

Sources & evidence

ORD record
ord-c4edcf98ae654b7dab2b02b9d7508144
Source dataset
uspto-grants-1992_10
Patent number
US05157026

Reaction notes

Loading…