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Sodium hydride → HCID 178437449、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 5-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazole | HCID 10053461 | — |
| 反応物 | 2-ethyl-7-methyl-3H-Imidazo[4,5-b]pyridine | HCID 18693036 | — |
| 生成物 | HCID 131717588 | HCID 131717588 | — |
| 生成物 | HCID 178437449 | HCID 178437449 | 154.5% |
反応手順
2-Ethyl-7-methyl-3(2'-(N-triphenylmethyltetrazol-5-yl)biphen-4-yl)methyl-3H-imidazo[4,5-b]pyridine was prepared according to the procedure described in Part A of Example 7, from 2-ethyl-7-methylimidazo[4,5-b]pyridine (0.5 g, 3.11 mmol), N-triphenylmethyl-5-(4'-bromomethylbiphenyl-2-yl)tetrazole (1.82 g, 3.26 mmol) and NaH (3.12 mmol). The crude product (1.9 g, foam) was purified by flash chromatography on silica-gel using EtOAc-hexanees (1:1.5) to give the desired product as a white solid (0.95 g, 47.5%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05157026 |
| 出典データセット | uspto-grants-1992_10 |
| ORD ID | ord-3819adc1f2a8477ea0320344597f7f55 |
| 出典メモ | uspto-grants-1992_10 |