Toluene → HCID 19814662, compound

HRID 466748Notes

Reaction equation

HRID 466748 reaction equation
[CH2:1]([S:3]([N:6]([S:8]([NH:11][C:12](=[O:20])OC1C=CC=CC=1)(=[O:10])=[O:9])[CH3:7])(=[O:5])=[O:4])[CH3:2].[NH2:21][C:22]1[N:27]=[C:26]([O:28][CH2:29][CH3:30])[CH:25]=[C:24]([O:31][CH2:32][CH3:33])[N:23]=1.[C:34]1(C)C=CC=CC=1>>[CH2:1]([S:3]([N:6]([S:8]([NH:11][C:12]([NH:21][C:22]1[N:23]=[C:24]([O:31][CH2:32][CH3:33])[CH:25]=[C:26]([O:28][CH2:29][CH3:30])[N:27]=1)=[O:20])(=[O:9])=[O:10])[CH2:7][CH3:34])(=[O:4])=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 1140TolueneHCID 23375612-amino-4,6-diethoxypyrimidineHCID 53751996HCID 53751996, compound

Product 1

HCID 19814662HCID 19814662, compoundYield 95.3%

Conditions

Temperature
110 °C

Procedure

65.2 g of phenyl (N-ethylsulfonyl-N-methylamino)sulfonylcarbamate are dissolved in 700 ml of toluene, 36.6 g of 2-amino-4,6-diethoxypyrimidine are added at room temperature, and the mixture is heated at 110° C. for 2 hours. After cooling to room temperature, the precipitate is filtered at 0° C. and washed with 200 ml of toluene. 82.6 g of the desired product of a purity of 98.1% are obtained, which corresponds to a yield of 95.3% of theory.

Workup

  1. temperatureAfter cooling to room temperature
  2. filtrationthe precipitate is filtered at 0° C.
  3. washwashed with 200 ml of toluene

Sources & evidence

ORD record
ord-c2cbed7d467741d48eec4a978f70830e
Source dataset
uspto-grants-1992_10
Patent number
US05157121

Reaction notes

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