Hydrochloric Acid → HCID 10858693, compound

HRID 466777Notes

Reaction equation

HRID 466777 reaction equation
[CH:1]([C@H:4]1[C:9]([O:10]C)=[N:8][C@@:7]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([CH3:12])[C:6]([O:20][CH3:21])=[N:5]1)([CH3:3])[CH3:2].Cl>C(OCC)C>[CH:1]([C@H:4]1[C:9](=[O:10])[NH:8][C@@:7]([CH2:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)([CH3:12])[C:6]([O:20][CH3:21])=[N:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10989847HCID 10989847, compound

Product 1

HCID 10858693HCID 10858693, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

1.44 g of (2S,5R)-2,5-dihydro-2-isopropyl-3,6-dimethoxy-5-benzyl-5-methylpyrazine in 30 ml of diethyl ether were treated at room temperature with 25 ml of 0.2 N HCl in diethyl ether. After 2 h, the mixture was evaporated under reduced pressure. Distillation of the residue yielded 0.94 g (69%) of crude (2S,5R)-2,5-dihydro-2-isopropyl-6-methoxy-5-benzyl-5-methyl-3-pyrazinone, boiling point 170° C./0.005 torr.

Workup

  1. customthe mixture was evaporated under reduced pressure
  2. distillationDistillation of the residue

Sources & evidence

ORD record
ord-94f71724d8b74a7791375289b37260af
Source dataset
uspto-grants-1992_10
Patent number
US05157145

Reaction notes

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