Hydrochloric Acid → 3-Methyl-2-furoic acid
Reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][O:4][C:3]=1[C:7]([O:9]C)=[O:8].[OH-].[Na+].Cl>>[CH3:1][C:2]1[CH:6]=[CH:5][O:4][C:3]=1[C:7]([OH:9])=[O:8]Participants
4
Procedure
A mixture of 3-methyl-2-furoic acid, methyl ester [20.0 g, 0.14 mole, 0.14 mole, Organic Synthesis 39, 49 (1959)] and 20% NaOH solution (46 mL) was refluxed under argon for 2 hours. The cooled mixture was acidified with concentrated HCl (28.5 mL). The resulting white precipitate was collected, washed with water and dried in vacuo to give the title acid (16.53 g, 94%) as a white crystalline solid, mp 132°-134° C.
Workup
- temperaturewas refluxed under argon for 2 hours
- customThe resulting white precipitate was collected
- washwashed with water
- customdried in vacuo
- customto give the title acid (16.53 g, 94%) as a white crystalline solid, mp 132°-134° C.
Sources & evidence
- ORD record
- ord-f09d79d4c6a34d01b747642602cf925c
- Source dataset
- uspto-grants-1992_10
- Patent number
- US05157134
Reaction notes
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