反应详情

A solution of 1,4-di-O-acetyl-2,3,6-tri-O-benzyl-D-galactopyranose (4.64 g, 8.67 mmol) in ether (10 mL) is treated with ethereal hydrogen chloride (0.2 g/mL, 25 mL). The mixture is stirred at room temperature during 48 h. The solvents are evaporated under reduced pressure so as to afford an oil. Flash chromatography on silica gel and elution with a graded mixture of carbon tetrachloride and ethyl acetate will afford 4-O-acetyl-2,3,6-tri-O-benzyl-α-D-galactopyranosyl chloride as an oil.

1. customThe solvents are evaporated under reduced pressure so as
2. customto afford an oil
3. washFlash chromatography on silica gel and elution
4. additionwith a graded mixture of carbon tetrachloride and ethyl acetate