Cyclohexylamine → HCID 15233410, compound

HRID 466980Notes

Reaction equation

HRID 466980 reaction equation
[S:1]1[CH:5]=[CH:4][S:3][C:2]1=[C:6]([C:13]([O:15]C(=O)C(C)(C)C)=O)[C:7]([O:9][CH:10]([CH3:12])[CH3:11])=[O:8].[CH:22]1([NH2:28])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>C(Cl)Cl>[S:3]1[CH:4]=[CH:5][S:1][C:2]1=[C:6]([C:13](=[O:15])[NH:28][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)[C:7]([O:9][CH:10]([CH3:11])[CH3:12])=[O:8]

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 19813258HCID 19813258, compound

Product 1

HCID 15233410HCID 15233410, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of isoproyl 2-(1,3-dithiol-2-ylidene)-2-(pivaloyloxycarbonyl)acetate (13.2 g) and cyclohexylamine (3.97 g) in methylene chloride (100ml) was stirred at room temperature for 2 hrs. The reaction mixture was washed with aqueous sodium hydroxide solution and water and then evaporated to dryness. The resultant residue was recrystallized from ethyl acetate to afford the pure product. (12.0 g, 91.6%)

Workup

  1. washThe reaction mixture was washed with aqueous sodium hydroxide solution and water
  2. customevaporated to dryness
  3. customThe resultant residue was recrystallized from ethyl acetate
  4. customto afford the pure product

Sources & evidence

ORD record
ord-5391de1f39ff42a2b3ab1a0d13b0ff2d
Source dataset
uspto-grants-1992_10
Patent number
US05158950

Reaction notes

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