N-bromobutanimide → HCID 178517109, compound

HRID 466991Notes

Reaction equation

HRID 466991 reaction equation
[NH:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4](=[O:12])[N:3]1[CH2:13][CH:14]=[CH2:15].[Br:16]N1C(=O)CCC1=O>O>[Br:16][CH2:15][CH:14]1[CH2:13][N:3]2[C:4](=[O:12])[NH:5][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=3[C:2]2=[N:1]1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 178456605HCID 178456605, compound

Product 1

HCID 178517109HCID 178517109, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 3,4-dihydro-4-imino-3-allyl-2(1H)-quinazolinone (0.5 g, 2.5 mmol) in water (30 mL) was added N-bromosuccinimide (443 mg, 2.5 mmol). The mixture was allowed to stir at room temperature for 30 minutes. The solid was collected by filtration and washed with water (10 mL) to afford 2-bromomethyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one (680 mg, 97%).

Workup

  1. filtrationThe solid was collected by filtration
  2. washwashed with water (10 mL)

Sources & evidence

ORD record
ord-a0e876b5d9e34f8cbaaf9d260bd02f98
Source dataset
uspto-grants-1992_10
Patent number
US05158953

Reaction notes

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