反应详情

Crude 2-(3-phenoxyphenoxy)-3-cyanopyridine (15 g) was stirred with Raney nickel alloy (15 g, 50:50) in refluxing 75% formic acid (200 ml) for 2 hours. The reaction mixture was diluted with water and then extracted repeatedly with ether. The combined ether extracts were dried, filtered and evaporated to give an orange oil. Filtration through a plug of silica (eluent hexane-ether, 1:1) afforded 2-(3-phenoxyphenoxy)-3-formylpyridine (3.03 g), infrared max. 1685 cm-1.

1. extractionextracted repeatedly with ether
2. dry with materialThe combined ether extracts were dried
3. filtrationfiltered
4. customevaporated
5. customto give an orange oil
6. filtrationFiltration through a plug of silica (eluent hexane-ether, 1:1)