Ammonia → HCID 70047169, compound

HRID 467053Notes

Reaction equation

HRID 467053 reaction equation
[CH2:1]1[CH2:15][C@H:14]2[C@@H:4]([CH2:5][C:6]3[C:16]4[C:9](=[CH:10][CH:11]=[CH:12][C:13]2=4)[NH:8][CH:7]=3)[NH:3][CH2:2]1.[C:17](OC(=O)C)(=[O:19])C.C([O-])(=O)C.[Na+].N>C(O)(=O)C>[OH:19][CH2:17][C:7]1[NH:8][C:9]2[C:16]3[C:6]=1[CH2:5][C@@H:4]1[C@@H:14]([C:13]=3[CH:12]=[CH:11][CH:10]=2)[CH2:15][CH2:1][CH2:2][NH:3]1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 6857537478-88-6

Product 1

HCID 70047169HCID 70047169, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1.0 mmol of ergoline is dissolved in 10 ml of glacial acetic acid. 5 ml (0.05 mol) of acetic anhydride and 0.8 g (0.01 mol) of anhydrous sodium acetate are added and allowed to stir overnight at room temperature. For working up, ice is added, it is stirred for 30 minutes and mixed with NH3 solution. After extraction with dichloromethane, drying of the organic phases on Na2SO4 and removal of the solvent in a vacuum, the raw product is obtained which is further purified by crystallization or chromatography.

Workup

  1. additionice is added
  2. stirringit is stirred for 30 minutes
  3. extractionAfter extraction with dichloromethane
  4. customdrying of the organic phases on Na2SO4 and removal of the solvent in a vacuum

Sources & evidence

ORD record
ord-b2c7a53c049c41f896b87cce567c05f8
Source dataset
uspto-grants-1992_10
Patent number
US05158957

Reaction notes

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