N-Benzyl-N-ethyl-4-methanesulphonamidophenethylamine → N-Ethyl-4-methanesulphonamidophenethylamine

HRID 467098Notes

Reaction equation

HRID 467098 reaction equation
[CH2:1]([N:8]([CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[CH:15][CH:14]=1)CC)[C:2]1C=CC=CC=1>C(O)C.[Pd]>[CH2:1]([NH:8][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[CH:15][CH:14]=1)[CH3:2]

Participants

4

Reactant 1

HCID 19813439N-Benzyl-N-ethyl-4-methanesulphonamidophenethylamine

Product 1

HCID 17890649N-Ethyl-4-methanesulphonamidophenethylamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

N-Benzyl-N-ethyl-4-methanesulphonamidophenethylamine (4.3 g, 12.9 mmole) was stirred under a hydrogen atmosphere (50 p.s.i.=344.7 kPa) in ethanol (50 ml) containing 10% Pd/C (0.5 g) for 5 hours. The mixture was then filtered, evaporated and the residue triturated with ether to give the title compound, yield 2.6 g, m.p. 125°-128°.

Workup

  1. filtrationThe mixture was then filtered
  2. customevaporated
  3. customthe residue triturated with ether

Sources & evidence

ORD record
ord-fa74015620eb47dc8eb12f2b170f6d55
Source dataset
uspto-grants-1992_10
Patent number
US05158964

Reaction notes

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