HCID 18648568, compound → HCID 53977342, compound

HRID 467131Notes

Reaction equation

HRID 467131 reaction equation
[C:1]([CH:6]([NH:20][C@H:21]([C:23]([CH:25]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28][CH:27]([C:35]([OH:37])=[O:36])[NH:26]1)=[O:24])[CH3:22])[CH2:7][CH2:8][NH:9]C(OCC1C=CC=CC=1)=O)([O:3][CH2:4][CH3:5])=[O:2]>CO.[Pd]>[C:1]([CH:6]([NH:20][C@H:21]([C:23]([CH:25]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28][CH:27]([C:35]([OH:37])=[O:36])[NH:26]1)=[O:24])[CH3:22])[CH2:7][CH2:8][NH2:9])([O:3][CH2:4][CH3:5])=[O:2]

Participants

4

Reactant 1

HCID 18648568HCID 18648568, compound

Product 1

HCID 53977342HCID 53977342, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1.1 g of N-(1-carboethoxy-3-benzoxycarbonylaminopropyl)-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid are dissolved in 150 ml of methanol and are hydrogenated in the presence of 100 mg of palladium/active charcoal (10% strength) at 40° C. under normal pressure. After the end of the reaction, the solution is filtered off from the catalyst and the solvent is stripped off in vacuo.

Workup

  1. customAfter the end of the reaction
  2. filtrationthe solution is filtered off from the catalyst

Sources & evidence

ORD record
ord-ab7d83664b554e1e8b6f7cf8cf97a7bf
Source dataset
uspto-grants-1992_10
Patent number
US05158959

Reaction notes

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