Trifluoroacetic acid → HCID 67805215, compound

HRID 467134Notes

Reaction equation

HRID 467134 reaction equation
[CH2:1]([O:8][C:9]([CH:11]1[CH2:19][CH:18]2[CH:13]([CH2:14][CH2:15][CH2:16][CH2:17]2)[N:12]1[C:20](=[O:31])[C@H:21]([CH3:30])[NH:22]C(OC(C)(C)C)=O)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>>[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].[CH2:1]([O:8][C:9]([CH:11]1[CH2:19][CH:18]2[CH:13]([CH2:14][CH2:15][CH2:16][CH2:17]2)[N:12]1[C:20](=[O:31])[C@H:21]([CH3:30])[NH2:22])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67806908HCID 67806908, compound

Product 1

HCID 67805215HCID 67805215, compound

Procedure

21.5 g of Boc-Ala-Oic-OBzl are dissolved in 50 ml of trifluoroacetic acid. The solution is concentrated in vacuo, and the residue is digested several times with diisopropyl ether and is dried in vacuo. Yield: 21 g. The proton signal for the tertiary-butyl group is completely absent in the NMR spectrum.

Workup

  1. concentrationThe solution is concentrated in vacuo
  2. customis dried in vacuo

Sources & evidence

ORD record
ord-66d416255257417ea11c25ada7225ae9
Source dataset
uspto-grants-1992_10
Patent number
US05158959

Reaction notes

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