Bromobenzene → 4-Methylbiphenyl

Participants

Reaction Steps

3.56 g (20 mmol) of sodium p-toluenesulfinate, 3.14 g (20 mmol) of bromobenzene, 0.0225 g (0.1 mmol) of palladium acetate, 0.0478 g (0.12 mmol) of 1,2-bis(diphenylphosphino)-ethane, 11.2 g (200 mmol) of calcium oxide and 60 ml of each solvent indicated in Table 1 were placed in a 100 ml round bottom flask and reacted at 150° C. in a nitrogen gas stream for 6 hours, respectively. After the completion of the reaction, the amount of 4-methyl-biphenyl formed was analyzed by means of high performance liquid chromatography. The results are shown in Table 1.

Provenance & Evidence