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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467329Generated: October 26, 2026

Tetramethyl-1,1-bisphosphono-1-hydroxy-4-phthalimidobutane → Alendronic Acid

https://huagongshe.com/reaction/467329

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetramethyl-1,1-bisphosphono-1-hydroxy-4-phthalimidobutaneHCID 86744990—
SolventHydrochloric AcidHCID 313—
ProductAlendronic AcidHCID 2088—

Reaction Steps

Tetramethyl-1,1-bisphosphono-1-hydroxy-4-phthalimidobutane 40 g (0.091 mole) from Step 4 was dissolved in 200 ml of 6N HCl and the solution refluxed for 18 hours.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05159108
Source datasetuspto-grants-1992_10
ORD IDord-23af33d53d694564a4d85c5344e477be
Source noteuspto-grants-1992_10