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HRID467330

反应详情

EQUATION

反应方程式

HRID 467330 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：COP(=O)(OC)C(O)(CCCN1C(=O)c2ccccc2C1=O)P(=O)(OC)OC
HCID9845824

未命名化合物

PRODUCTS

生成物

1
结构：NCCCC(O)(P(=O)(O)O)P(=O)(O)O
HCID2088

Alendronic Acid

C4H13NO7P2

PROCEDURE

实验过程

contacting tetramethyl phthalimido-1-hydroxybutylidene-bisphosphonate from Step (b) with aqueous hydrochloric acid at a temperature in the range of 80° C. to reflux to form 4-amino-1-hydroxybutylidene-bisphosphonic acid.

WORKUP

后处理

  1. customin the range of 80° C.
  2. temperatureto reflux