反应详情

A solution of 20 mmol of bromide (example 141) and 30 mmol of triphenyl phosphine in 60 ml of ethanol was refluxed 20 hours under nitrogen and then cooled and evaporated in vacuo. The residue was chromatographed on silica gel using first CHCl3 to elute starting material residues and then 5% CH3OH in CHCl3 to elute the product. Evaporation of pure fractions yielded the title compound as a viscous oil.

1. temperaturecooled
2. customevaporated in vacuo
3. customThe residue was chromatographed on silica gel using first CHCl3
4. washto elute
5. wash5% CH3OH in CHCl3 to elute the product
6. customEvaporation of pure fractions