HCID 14210337, compound → HCID 7408314, compound

HRID 467353Notes

Reaction equation

HRID 467353 reaction equation
[NH:1]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[C@H:2]([C:10]([NH:12][CH2:13][C:14]([NH:16][CH2:17][C:18]([O:20]CC1C=CC=CC=1)=[O:19])=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>[Pd].CO>[NH:1]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[C@H:2]([C:10]([NH:12][CH2:13][C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 14210337HCID 14210337, compound

Product 1

HCID 7408314HCID 7408314, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

7.0 g Boc-Phe-Gly-Gly-OBzl was reduced in the presence of Pd-black as a catalyst in 200 ml MeOH, and this was followed by concentration. The resulting concentrate, after the addition of 1.72 ml CHA, was crystallized with AcOEt and collected by filtration.

Workup

  1. concentrationthis was followed by concentration
  2. concentrationThe resulting concentrate
  3. additionafter the addition of 1.72 ml CHA
  4. customwas crystallized with AcOEt
  5. filtrationcollected by filtration

Sources & evidence

ORD record
ord-8fd757bea52a4a1cb12db51f1edcb258
Source dataset
uspto-grants-1992_10
Patent number
US05159061

Reaction notes

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