HRID467356

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID89529

4,7-Methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-hydroxy-

C9H9NO3

结构：Cc1ccc(CSC[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc1

HCID7010551

未命名化合物

结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)O

HCID14330680

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(CSC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCC(=O)O)cc1

HCID131717606

未命名化合物

PROCEDURE

实验过程

Using Boc-Phe-βAla-OH (prepared with 1.31 g Boc-Phe-βAla-OH.CHA), 1.02 g Boc-Cys(MBzl)-OH, 0.60 g HONB and 0.68 g DCC, the desired product was obtained in exactly the same manner as in Example 1-(XX), and was then crystallized with ether and collected by filtration.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6ddf0c2b6db74465a115e68024445991
来源数据集: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05159061
来源说明: uspto-grants-1992_10

反应 SMILES

[NH:1]([C:18]([O:20]C(C)(C)C)=O)[C@H:2]([C:10]([NH:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH:25]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[C@H:26](C(O)=O)[CH2:27][S:28][CH2:29][C:30]1[CH:36]=[CH:35][C:33]([CH3:34])=[CH:32][CH:31]=1.C1C2C3C(=O)N(O)C(=O)C3C1C=C2.C1CCC(N=C=NC2CCCCC2)CC1>>[NH:25]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[C@H:26]([C:18]([NH:1][C@H:2]([C:10]([NH:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1)=[O:20])[CH2:27][S:28][CH2:29][C:30]1[CH:36]=[CH:35][C:33]([CH3:34])=[CH:32][CH:31]=1