HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → Boc-Cys(MBzl)-Phe-betaAla-OH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 3a,4,7,7a-Tetrahydro-2-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione | HCID 89529 | — |
| Reactant | N-alpha-t-Butyloxycarbonyl-S-(4-methyl-benzyl)-L-cysteine | HCID 7010551 | — |
| Reactant | Boc-Phe-betaAla-OH | HCID 14330680 | — |
| Product | Boc-Cys(MBzl)-Phe-betaAla-OH | HCID 131717606 | — |
Reaction Steps
Using Boc-Phe-βAla-OH (prepared with 1.31 g Boc-Phe-βAla-OH.CHA), 1.02 g Boc-Cys(MBzl)-OH, 0.60 g HONB and 0.68 g DCC, the desired product was obtained in exactly the same manner as in Example 1-(XX), and was then crystallized with ether and collected by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05159061 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-6ddf0c2b6db74465a115e68024445991 |
| Source note | uspto-grants-1992_10 |