HRID467360

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID82035

L-Asparagine, N2-[(1,1-dimethylethoxy)carbonyl]-

C9H16N2O5

HCID89529

4,7-Methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-hydroxy-

C9H9NO3

结构：Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](COCc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc2ccc(OCc3ccccc3)cc2)C(=O)OCc2ccccc2)cc1

HCID178427520

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](COCc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc2ccc(OCc3ccccc3)cc2)C(=O)OCc2ccccc2)cc1

HCID178427518

未命名化合物

PROCEDURE

实验过程

Using 2.20 g Boc-Ser(Bzl)-Phe-D-Arg(Tos)-Tyr(Bzl)-OBzl, 0.61 g Boc- Asn-OH, 0.51 g HONB and 0.58 g DCC, the desired product was obtained in exactly the same manner as in Example 1-(IV).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e3f5450518a243ccaaa742b0cf103a13
来源数据集: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05159061
来源说明: uspto-grants-1992_10

反应 SMILES

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:12]([NH:14][C@H:15]([C:23]([NH:25][C@@H:26]([C:44]([NH:46][C@H:47]([C:63]([O:65][CH2:66][C:67]1[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=1)=[O:64])[CH2:48][C:49]1[CH:54]=[CH:53][C:52]([O:55][CH2:56][C:57]2[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=2)=[CH:51][CH:50]=1)=[O:45])[CH2:27][CH2:28][CH2:29][NH:30][C:31](=[NH:43])[NH:32][S:33]([C:36]1[CH:42]=[CH:41][C:39]([CH3:40])=[CH:38][CH:37]=1)(=[O:35])=[O:34])=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[CH3:80][C:81]([O:84][C:85]([NH:87][C@H:88]([C:93]([OH:95])=O)[CH2:89][C:90]([NH2:92])=[O:91])=[O:86])([CH3:83])[CH3:82].C1C2C3C(=O)N(O)C(=O)C3C1C=C2.C1CCC(N=C=NC2CCCCC2)CC1>>[NH:87]([C:85]([O:84][C:81]([CH3:80])([CH3:82])[CH3:83])=[O:86])[C@H:88]([C:93]([NH:1][C@H:2]([C:12]([NH:14][C@H:15]([C:23]([NH:25][C@@H:26]([C:44]([NH:46][C@H:47]([C:63]([O:65][CH2:66][C:67]1[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=1)=[O:64])[CH2:48][C:49]1[CH:50]=[CH:51][C:52]([O:55][CH2:56][C:57]2[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=2)=[CH:53][CH:54]=1)=[O:45])[CH2:27][CH2:28][CH2:29][NH:30][C:31](=[NH:43])[NH:32][S:33]([C:36]1[CH:42]=[CH:41][C:39]([CH3:40])=[CH:38][CH:37]=1)(=[O:34])=[O:35])=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:95])[CH2:89][C:90](=[O:91])[NH2:92]