HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 2-Acetamidooxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 4-Oxazolecarboxylic acid, 2-(acetylamino)-, ethyl ester | HCID 215373 | — |
| Reactant | Ethyl 2-amino-1,3-oxazole-4-carboxylate | HCID 319549 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Acetamidooxazole-4-carboxylic acid | HCID 84011893 | — |
Reaction Steps
1.0 g (6.41 mmol) ethyl 2-aminooxazole-4-carboxylate and 9.10 mL (96.3 mmol) Ac2O are stirred at r.t. over the weekend. Then the solvent is removed in vacuo. Some toluene is added and all volatile components are removed in vacuo again. This procedure is repeated three times. The crude product is used without further purification. b) 1.31 g (6.60 mmol) of ethyl 2-acetamidooxazole-4-carboxylate are added to 33 mL EtOH. 0.55 g (13.2 mmol) LiOH are added and the resulting mixture is stirred at r.t. over night. Then the EtOH is removed in vacuo and diluted aq. HCl is added and the resulting precipitate is collected, washed with cold water and dried. The resulting product is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08623860B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-79ab2ff40fbf4f85b71afd236327c6fb |
| Source note | uspto-grants-2014_01 |