反应详情

1.0 g (6.41 mmol) ethyl 2-aminooxazole-4-carboxylate and 9.10 mL (96.3 mmol) Ac2O are stirred at r.t. over the weekend. Then the solvent is removed in vacuo. Some toluene is added and all volatile components are removed in vacuo again. This procedure is repeated three times. The crude product is used without further purification. b) 1.31 g (6.60 mmol) of ethyl 2-acetamidooxazole-4-carboxylate are added to 33 mL EtOH. 0.55 g (13.2 mmol) LiOH are added and the resulting mixture is stirred at r.t. over night. Then the EtOH is removed in vacuo and diluted aq. HCl is added and the resulting precipitate is collected, washed with cold water and dried. The resulting product is used without further purification.

1. customThen the solvent is removed in vacuo
2. additionSome toluene is added
3. customall volatile components are removed in vacuo again
4. customThe crude product is used without further purification
5. customThen the EtOH is removed in vacuo and diluted aq. HCl
6. additionis added
7. customthe resulting precipitate is collected
8. washwashed with cold water
9. customdried
10. customThe resulting product is used without further purification