Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2-bromopropionate | HCID 95576 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67060788 | HCID 67060788 | 95.7% |
Reaction Steps
2.97 g of potassium carbonate and 1.97 g of methyl 2-bromopropanoate are added to a solution of 2 g of tert-butyl piperazine-1-carboxylate in 36 ml of DMF, and then it is heated at 60° C. for 1 hour. After it returns to RT, 150 ml of EtOAc is added, it is washed with water, with brine, dried over Na2SO4 and then evaporated to dryness. 2.8 g of the expected compound is obtained in the form of a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08623862B2 |
|---|
| Source dataset | uspto-grants-2014_01 |
|---|
| ORD ID | ord-4ee90970a6484f18bfdd11cff3e5d26e |
|---|
| Source note | uspto-grants-2014_01 |
|---|
