Ethyl Acetate → HCID 67060788, compound

HRID 467516Notes

Reaction equation

HRID 467516 reaction equation
C(=O)([O-])[O-].[K+].[K+].Br[CH:8]([CH3:13])[C:9]([O:11][CH3:12])=[O:10].[N:14]1([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.CCOC(C)=O>CN(C=O)C>[CH3:12][O:11][C:9](=[O:10])[CH:8]([N:17]1[CH2:16][CH2:15][N:14]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:19][CH2:18]1)[CH3:13]

Participants

6

Reactant 4

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 95576Methyl 2-bromopropionateHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 67060788HCID 67060788, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

2.97 g of potassium carbonate and 1.97 g of methyl 2-bromopropanoate are added to a solution of 2 g of tert-butyl piperazine-1-carboxylate in 36 ml of DMF, and then it is heated at 60° C. for 1 hour. After it returns to RT, 150 ml of EtOAc is added, it is washed with water, with brine, dried over Na2SO4 and then evaporated to dryness. 2.8 g of the expected compound is obtained in the form of a colorless oil.

Workup

  1. customreturns to RT
  2. washit is washed with water, with brine
  3. dry with materialdried over Na2SO4
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-4ee90970a6484f18bfdd11cff3e5d26e
Source dataset
uspto-grants-2014_01
Patent number
US08623862B2

Reaction notes

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