反应详情

This intermediate was synthesized in substantially the same way as intermediate (vi), 6-((2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline, by condensation of 7-bromo-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid methyl ester with (2S,3′S)-2-Methyl-[1,3]bipyrrolidinyl.