HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,3'S)-2-Methyl-[1,3]bipyrrolidinyl → 7-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,3'S)-2-Methyl-[1,3]bipyrrolidinyl | HCID 59401808 | — |
| Reactant | HCID 67469327 | HCID 67469327 | — |
| Reactant | 6-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline | HCID 68211015 | — |
| Product | 7-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid methyl ester | HCID 68211019 | — |
Reaction Steps
This intermediate was synthesized in substantially the same way as intermediate (vi), 6-((2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline, by condensation of 7-bromo-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid methyl ester with (2S,3′S)-2-Methyl-[1,3]bipyrrolidinyl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08623877B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-79f48bfa02d64971a0f5717e6508eb2e |
| Source note | uspto-grants-2014_01 |