2-Bromo-6-(pyrrolidin-1-yl)pyridine → 6-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-2-(6-pyrrolidin-1-yl-pyridin-2-yl)-1,2,3,4-tetrahydro-isoquinoline

HRID 467575Notes

Reaction equation

HRID 467575 reaction equation
[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C@H:7]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:8]1.Br[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([N:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)[N:24]=1>>[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C@H:7]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH2:18][N:17]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([N:29]4[CH2:33][CH2:32][CH2:31][CH2:30]4)[N:24]=2)[CH2:16][CH2:15]3)[CH2:8]1

Participants

3

Reactant 2

HCID 154702772-Bromo-6-(pyrrolidin-1-yl)pyridineHCID 674693316-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

Product 1

HCID 546700976-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-2-(6-pyrrolidin-1-yl-pyridin-2-yl)-1,2,3,4-tetrahydro-isoquinoline

Procedure

The title compound was synthesized in substantially the same way as Example 1 by condensation of 6-((2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-1,2,3,4-tetrahydro-isoquinoline with 2-bromo-6-pyrrolidin-1-yl-pyridine.

Sources & evidence

ORD record
ord-32a20ac00b6f43519a90ab441a6cfa62
Source dataset
uspto-grants-2014_01
Patent number
US08623877B2

Reaction notes

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