HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-6-(pyrrolidin-1-yl)pyridine → 6-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-2-(6-pyrrolidin-1-yl-pyridin-2-yl)-1,2,3,4-tetrahydro-isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-6-(pyrrolidin-1-yl)pyridine | HCID 15470277 | — |
| Reactant | 6-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline | HCID 67469331 | — |
| Product | 6-((2S,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-2-(6-pyrrolidin-1-yl-pyridin-2-yl)-1,2,3,4-tetrahydro-isoquinoline | HCID 54670097 | — |
Reaction Steps
The title compound was synthesized in substantially the same way as Example 1 by condensation of 6-((2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-1,2,3,4-tetrahydro-isoquinoline with 2-bromo-6-pyrrolidin-1-yl-pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08623877B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-32a20ac00b6f43519a90ab441a6cfa62 |
| Source note | uspto-grants-2014_01 |