Potassium Carbonate → HCID 66584337, compound

HRID 467599Notes

Reaction equation

HRID 467599 reaction equation
Cl[C:2]1[NH:3][CH2:4][N:5]=[C:6]2[C:11]=1[CH:10]=[C:9]([N+:12]([O-:14])=[O:13])[C:8]([F:15])=[CH:7]2.C([O-])([O-])=O.[K+].[K+]>CC#N>[NH:5]([C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:15])=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 178526400HCID 178526400, compound

Product 1

HCID 66584337HCID 66584337, compoundYield 345.9%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Compounds 6 (3 g, 13.18 mmole) and 17 (3.9 g, 13.18 mmole) were combined in CH3CN (25 mL) and heated for one hr. Mass spectroscopy indicated no starting material. Saturated K2CO3 was added and the reaction was extracted 3× with EtOAc. The organic layers were combined, washed with brine and concentrated in vacuo to give 6.48 g of 7 (78.4%).

Workup

  1. temperatureheated for one hr
  2. extractionthe reaction was extracted 3× with EtOAc
  3. washwashed with brine
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-be02468dd7f940baa35716ad0b2f5c33
Source dataset
uspto-grants-2014_01
Patent number
US08623883B2

Reaction notes

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