Prolinol → HCID 58548154, compound

HRID 467709Notes

Reaction equation

HRID 467709 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:7][CH2:6][CH2:5][NH:4]1.[CH:8]1([C:11]2[N:16]=[C:15]([C:17]([NH:19][C:20]3[CH:28]=[N:27][CH:26]=[CH:25][C:21]=3[C:22](O)=[O:23])=[O:18])[C:14]([NH:29][C:30]3[CH:31]=[N:32][CH:33]=[N:34][CH:35]=3)=[CH:13][CH:12]=2)[CH2:10][CH2:9]1>>[OH:1][CH2:2][CH:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:22]([C:21]1[CH:25]=[CH:26][N:27]=[CH:28][C:20]=1[NH:19][C:17]([C:15]1[C:14]([NH:29][C:30]2[CH:31]=[N:32][CH:33]=[N:34][CH:35]=2)=[CH:13][CH:12]=[C:11]([CH:8]2[CH2:10][CH2:9]2)[N:16]=1)=[O:18])=[O:23]

Participants

3

Reactant 2

HCID 90908ProlinolHCID 700980543-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid

Product 1

HCID 58548154HCID 58548154, compoundYield 29%

Procedure

According to the general method described in step 3 of example 53, reaction of 2-hydroxymethylpyrrolidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound as off-white solid (29%).

Sources & evidence

ORD record
ord-cb5d74a0dc404cd3961cb3a894e231b6
Source dataset
uspto-grants-2014_01
Patent number
US08623866B2

Reaction notes

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