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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467722Generated: October 30, 2026

4-amino-N,1-dimethyl-1H-pyrazole-3-carboxamide hydrochloride → 3-Amino-N-(1-methyl-3-(methylcarbamoyl)-1H-pyrazol-4-yl)-6-(tetrahydrofuran-2-yl)pyrazine-2-carboxamide

https://huagongshe.com/reaction/467722

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-amino-N,1-dimethyl-1H-pyrazole-3-carboxamide hydrochlorideHCID 44630897—
Reactant3-Amino-6-(tetrahydrofuran-2-yl)pyrazine-2-carboxylic acid methyl esterHCID 70098790—
Product3-Amino-N-(1-methyl-3-(methylcarbamoyl)-1H-pyrazol-4-yl)-6-(tetrahydrofuran-2-yl)pyrazine-2-carboxamideHCID 7011411364%

Reaction Steps

According to the procedure described in step 2 of example 14, 3-amino-6-(tetrahydrofuran-2-yl)pyrazine-2-carboxylic acid methyl ester was reacted with 4-amino-1-methyl-1H-pyrazole-3-carboxylic acid methylamide hydrochloride to obtain the title compound as yellow solid (64%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08623866B2
Source datasetuspto-grants-2014_01
ORD IDord-8b4bb89259ce4585b03dd68b3d4cdc36
Source noteuspto-grants-2014_01