反应详情

To a solution of 2-hydroxy-2-methylpropyl 5-(2-hydroxy-2-methylpropoxy)-2-nitrobenzoate (0.24 g, 733 μmol) in MeOH (10 ml) at r.t was added NaOH 1 N (2.2 ml, 2.2 mmol). The solution was stirred at r.t overnight. 2.2 ml 1 N HCl were added. The solvents were evaporated. The residue was dissolved in methylenechloride/MeOH 9:1 (100 ml), washed with 10 ml H2O, dried over MgSO4, filtered and evaporated to give the title compound (149 mg, 80%) as off-white solid.

1. customThe solvents were evaporated
2. dissolutionThe residue was dissolved in methylenechloride/MeOH 9:1 (100 ml)
3. washwashed with 10 ml H2O
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated