HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 67437509, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Cispentacin | HCID 73305 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Solvent | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Product | HCID 67437509 | HCID 67437509 | — |
Reaction Steps
55 mg (0.43 mmol) cis-(±)-2-amino-cyclopentanecarboxylic acid are suspended in 900 μL (25 eq) isopropylamine and 205 mg (0.064 mmol, 1.5 eq) TBTU and 550 μL DMF are added. The mixture is stirred for 16 h and the reaction mixture is taken up in DCM/MeOH/NH3(aq) 9/1/0.1 and combined with 7 mL silica gel. After all the volatile constituents have been eliminated in vacuo the residue is chromatographed (silica gel DCM/MeOH/NH3 9/1/0.1). 63 mg of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08623887B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-c839e5a9a01f4e6eb00004bc367f7a67 |
| Source note | uspto-grants-2014_01 |