反应详情

55 mg (0.43 mmol) cis-(±)-2-amino-cyclopentanecarboxylic acid are suspended in 900 μL (25 eq) isopropylamine and 205 mg (0.064 mmol, 1.5 eq) TBTU and 550 μL DMF are added. The mixture is stirred for 16 h and the reaction mixture is taken up in DCM/MeOH/NH3(aq) 9/1/0.1 and combined with 7 mL silica gel. After all the volatile constituents have been eliminated in vacuo the residue is chromatographed (silica gel DCM/MeOH/NH3 9/1/0.1). 63 mg of the title compound are obtained.

1. customis chromatographed (silica gel DCM/MeOH/NH3 9/1/0.1)