HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide → N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide | HCID 58049370 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide | HCID 46916730 | 95.1% |
Reaction Steps
A mixture of N-(tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide (50 mg), 10% palladium-carbon (50 mg) and methanol (15 mL) was stirred in a nitrogen atmosphere for 2 hours at room temperature. The insoluble matter was filtered off and methanol was distilled off under reduced pressure to give the titled compound (48 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08623898B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-d15a8106b1404230a679aa89ae608dfc |
| Source note | uspto-grants-2014_01 |