Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467963Generated: October 30, 2026

N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide → N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide

https://huagongshe.com/reaction/467963

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamideHCID 58049370—
CatalystHCID 178418390HCID 178418390—
SolventMethanolHCID 887—
ProductN-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamideHCID 4691673095.1%

Reaction Steps

A mixture of N-(tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide (50 mg), 10% palladium-carbon (50 mg) and methanol (15 mL) was stirred in a nitrogen atmosphere for 2 hours at room temperature. The insoluble matter was filtered off and methanol was distilled off under reduced pressure to give the titled compound (48 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08623898B2
Source datasetuspto-grants-2014_01
ORD IDord-d15a8106b1404230a679aa89ae608dfc
Source noteuspto-grants-2014_01