Isopropyl iodide → Latanoprost

Participants

Reaction Steps

To 1.0 gram of Latanoprost L-arginine salt (2) in MeOH/H2O (4:1, 20 mL) is added 2.01 equivalents of isopropyl iodide (99%, Cat #148938, Sigma-Aldrich, St. Louis, Mo.). and the solution is stirred overnight. Saturated aqueous ammonium acetate is added along with ethyl acetate and the layers are separated. The organic layer is separated, and the solvents removed in vaccuo, and the material is chromatographed to give latanoprost as the isopropyl ester (6).

Provenance & Evidence