HRID468037

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6362

2-Iodopropane

C3H7I

HCID8857

Ethyl acetate

C4H8O2

HCID517165

Ammonium acetate

C2H7NO2

$结构：CC(C)OC(=O)CCC/C=C\C[C@@H]1[C@@H](CC[C@@H](O)CCc2ccccc2)[C@H](O)C[C@@H]1O.N=C(N)NCCC[C@H](N)C(=O)O$

HCID178459547

未命名化合物

PRODUCTS

生成物

$结构：CC(C)OC(=O)CCC/C=C\C[C@@H]1[C@@H](CC[C@@H](O)CCc2ccccc2)[C@H](O)C[C@@H]1O$

HCID5311221

Latanoprost

C26H40O5

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID22242641

Methanol--water (1/1)

CH6O2

PROCEDURE

实验过程

To 1.0 gram of Latanoprost L-arginine salt (2) in MeOH/H2O (4:1, 20 mL) is added 2.01 equivalents of isopropyl iodide (99%, Cat #148938, Sigma-Aldrich, St. Louis, Mo.). and the solution is stirred overnight. Saturated aqueous ammonium acetate is added along with ethyl acetate and the layers are separated. The organic layer is separated, and the solvents removed in vaccuo, and the material is chromatographed to give latanoprost as the isopropyl ester (6).

WORKUP

后处理

customthe layers are separated
customThe organic layer is separated
customthe solvents removed in vaccuo
customthe material is chromatographed