Hydrochloric Acid → HCID 86604847, compound

HRID 468084Notes

Reaction equation

HRID 468084 reaction equation
[N:1]([CH2:4][CH2:5][CH2:6][C:7]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[N:11]([C:12]([N:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH3:15])=[O:13])[N:10]=[C:9]([C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=2[F:28])[S:8]1)=[N+]=[N-].Cl>CO.[Pt]=O>[NH2:1][CH2:4][CH2:5][CH2:6][C:7]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[N:11]([C:12]([N:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH3:15])=[O:13])[N:10]=[C:9]([C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=2[F:28])[S:8]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86604845HCID 86604845, compound

Product 1

HCID 86604847HCID 86604847, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-(3-azidopropyl)-N-tert-butoxy-5-(2,5-difluorophenyl)-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide (0.032 g, 0.065 mmol) and platinum oxide (15 mg) in methanol (3 mL) was added HCl (5.3 M solution in dioxane, 0.05 mL). After stirring under a hydrogen balloon for 1 hour, the mixture was filtered and the filtrate was concentrated under reduced pressure to provide the product.

Workup

  1. filtrationthe mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customto provide the product

Sources & evidence

ORD record
ord-1a864cd83af643e38643b60a39fbdaa7
Source dataset
uspto-grants-2014_01
Patent number
US08623895B2

Reaction notes

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