Potassium Carbonate → (4-Cyclohexyl-phenyl)-(3-piperazin-1-yl-azetidin-1-yl)-methanone

HRID 468089Notes

Reaction equation

HRID 468089 reaction equation
[CH:1]1([C:7]2[CH:30]=[CH:29][C:10]([C:11]([N:13]3[CH2:16][CH:15]([N:17]4[CH2:22][CH2:21][N:20](C(=O)C(F)(F)F)[CH2:19][CH2:18]4)[CH2:14]3)=[O:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+]>CO.O>[CH:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:11]([N:13]3[CH2:16][CH:15]([N:17]4[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]4)[CH2:14]3)=[O:12])=[CH:29][CH:30]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 596260481-{4-[1-(4-Cyclohexyl-benzoyl)-azetidin-3-yl]-piperazin-1-yl}-2,2,2-trifluoro-ethanone

Product 1

HCID 59626057(4-Cyclohexyl-phenyl)-(3-piperazin-1-yl-azetidin-1-yl)-methanone

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of compound 1i (0.95 g, 2.24 mmol) in CH3OH (16 mL) and H2O (4 mL) was added K2CO3 (0.8 g, 5.79 mmol). The mixture was stirred at room temperature for 1 h. After filtration, the solvent was removed by evaporation. The crude compound 1j was used in the next reaction without further purification. MS m/z (M+H+) 328.2.

Workup

  1. filtrationAfter filtration
  2. customthe solvent was removed by evaporation
  3. customThe crude compound 1j was used in the next reaction without further purification

Sources & evidence

ORD record
ord-f863273e6a9f4bd387b3f5c5489f4585
Source dataset
uspto-grants-2014_01
Patent number
US08623858B2

Reaction notes

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