反应详情

To a solution of 5-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (0.3 g) in ethyl acetate (10 ml) was added activated manganese dioxide (2.4 g) and the mixture was refluxed for 2 hours under stirring vigorously. After allowing to stand to room temperature, manganese dioxide was filtered off. The filtrate was evaporated in vacuo, and the residual precipitate was recrystallized from diethyl ether to give 5-formyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (0.15 g).

1. temperaturethe mixture was refluxed for 2 hours
2. customto stand to room temperature
3. filtrationmanganese dioxide was filtered off
4. customThe filtrate was evaporated in vacuo
5. customthe residual precipitate was recrystallized from diethyl ether