反应详情

To a solution of compound 7c (1.2 g, 3.41 mmol) in CH2Cl2 (12 mL) was added TFA (3 mL). The reaction mixture was stirred at room temperature for 4.5 h, concentrated, and to the resulting residue was added aq. NaHCO3. The mixture was extracted with 2% MeOH/CH2Cl2 (3×). The organic solution was dried over Na2SO4 and concentrated to give compound 5e, which was used in the next reaction without further purification.

1. concentrationconcentrated
2. additionto the resulting residue was added aq. NaHCO3
3. extractionThe mixture was extracted with 2% MeOH/CH2Cl2 (3×)
4. dry with materialThe organic solution was dried over Na2SO4
5. concentrationconcentrated