反应详情

A mixture of compound 35c (340 mg, 1.18 mmol) and LiOH (114 mg, 4.74 mmol) in THF/MeOH/H2O (3/3/3 mL) was stirred for 4 h. A 15% citric acid solution (10 mL) was added. The mixture was then extracted with EtOAc (3×). The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The resultant residue, compound 35d (230 mg) was dried under reduced pressure for 18 h and used without further purification.

1. extractionThe mixture was then extracted with EtOAc (3×)
2. washThe combined organic extracts were washed with brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated under reduced pressure
5. dry with materialThe resultant residue, compound 35d (230 mg) was dried under reduced pressure for 18 h
6. customused without further purification