HCID 178473447, compound → HCID 20384868, compound

HRID 46820Notes

Reaction equation

HRID 46820 reaction equation
[CH3:1][N:2]([CH3:22])[C:3]1[N:8]=[C:7]([NH:9][C:10](OCC)=[O:11])[N+:6]([O-:15])=[C:5]([NH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:4]=1>CN(C)C=O>[CH3:1][N:2]([CH3:22])[C:3]1[CH:4]=[C:5]([NH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[N:6]2[O:15][C:10](=[O:11])[N:9]=[C:7]2[N:8]=1

Participants

3

Reactant 1

HCID 178473447HCID 178473447, compound

Product 1

HCID 20384868HCID 20384868, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1 G. of diethyl 6-dimethylamino-2,4-pyrimidine-dicarbamate-3-oxide is heated to 140° C. for 30 minutes in 10 ml. of N,N-dimethylformamide under an argon atmosphere. The solution is cooled and the solvent is evaporated under reduced pressure. The crystalline residue is recrystallized from methylene chloride/ethanol, there being obtained pure ethyl 5-dimethylamino-2-oxo-2H-[1,2,4]oxadiazolo[2,3-a]pyrimidine-7-carbamate, having a melting point of 230°-240° C.

Workup

  1. temperatureThe solution is cooled
  2. customthe solvent is evaporated under reduced pressure
  3. customThe crystalline residue is recrystallized from methylene chloride/ethanol, there

Sources & evidence

ORD record
ord-a0610cada966402abea7c32d81dadb0c
Source dataset
uspto-grants-1979_11
Patent number
US04175190

Reaction notes

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