反应详情

A mixture of 100 parts of 1-chloro-2-nitro-4-(trifluoromethyl)benzene, 90 parts of 3-amino-1-propanol and 200 parts of butanol is stirred and heated till reflux. Stirring at reflux is continued overnight. The reaction mixture is cooled and evaporated. Water is added to the residue and the whole is acidified with a hydrochloric acid solution. The product is extracted with methylbenzene. The extract is dried, filtered and evaporated. The solid residue is crystallized from petroleumether. The product is filtered off and dried, yielding 141 parts (100%) of 3-{[2-nitro-4-(trifluoromethyl)phenyl]amino}-1-propanol.

1. temperatureheated
2. temperaturetill reflux
3. stirringStirring
4. temperatureat reflux
5. temperatureThe reaction mixture is cooled
6. customevaporated
7. additionWater is added to the residue
8. extractionThe product is extracted with methylbenzene
9. customThe extract is dried
10. filtrationfiltered
11. customevaporated
12. customThe solid residue is crystallized from petroleumether
13. filtrationThe product is filtered off
14. customdried