HRID468573

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)C(=O)N(c2ccc(N)c(C(F)(F)F)c2)C(=O)N1CCCCCN1C(=O)N(c2ccc(N)c(C(F)(F)F)c2)C(=O)C1(C)C

HCID49764091

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Nc1ccc(N2C(=O)N(CCCCCN3C(=O)N(c4ccc(NC(C)=O)c(C(F)(F)F)c4)C(=O)C3(C)C)C(C)(C)C2=O)cc1C(F)(F)F

HCID87135224

未命名化合物

收率 52%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6367

Acetyl chloride

C2H3ClO

CONDITIONS

反应条件

温度: 23 °C

PROCEDURE

实验过程

The compound of Example 8 (161 mg, 0.25 mmol) is mixed under an argon atmosphere with acetyl chloride (10 ml) and stirring is maintained for 15 hours at 23° C. The reaction mixture is then evaporated to dryness (entrainment with toluene) and the residue obtained is purified on a silica column (eluent: CH2Cl2/EtOH from 99/1 to 90/10). After evaporation, the expected compound is obtained in the form of a cream coloured foam with a yield of 52%.

WORKUP

后处理

customThe reaction mixture is then evaporated to dryness (entrainment with toluene)
customthe residue obtained
customis purified on a silica column (eluent: CH2Cl2/EtOH from 99/1 to 90/10)
customAfter evaporation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b1379cbae4ff41e2afd9e7d1a7d0d049
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08624037B2
来源说明: uspto-grants-2014_01

反应 SMILES

[CH2:1]([N:26]1[C:30]([CH3:32])([CH3:31])[C:29](=[O:33])[N:28]([C:34]2[CH:39]=[CH:38][C:37]([NH2:40])=[C:36]([C:41]([F:44])([F:43])[F:42])[CH:35]=2)[C:27]1=[O:45])[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:10]([CH3:12])([CH3:11])[C:9](=[O:13])[N:8]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[C:16]([C:21]([F:24])([F:23])[F:22])[CH:15]=2)[C:7]1=[O:25]>C(Cl)(=O)C>[CH2:5]([N:6]1[C:10]([CH3:12])([CH3:11])[C:9](=[O:13])[N:8]([C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:29](=[O:33])[CH3:30])=[C:16]([C:21]([F:22])([F:23])[F:24])[CH:15]=2)[C:7]1=[O:25])[CH2:4][CH2:3][CH2:2][CH2:1][N:26]1[C:30]([CH3:32])([CH3:31])[C:29](=[O:33])[N:28]([C:34]2[CH:39]=[CH:38][C:37]([NH:40][C:9](=[O:13])[CH3:10])=[C:36]([C:41]([F:44])([F:43])[F:42])[CH:35]=2)[C:27]1=[O:45]