HRID468575

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)NC(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C1=O

HCID4493

Nilutamide

C12H10F3N3O4

结构：CC1(C)C(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C(=O)N1CCCCCN1C(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C(=O)C1(C)C

HCID46937259

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(N2C(=O)N(CCCCCN3C(=O)N(c4ccc([N+](=O)[O-])c(C)c4)C(=O)C3(C)C)C(C)(C)C2=O)ccc1[N+](=O)[O-]

HCID49764092

未命名化合物

收率 67%

PROCEDURE

实验过程

The experimental protocol used is the same as that described for the synthesis of the compound of Example 2, intermediate 10.1 replacing 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-imidazolidine-2,4-dione. The expected compound is obtained in the form of a white solid with a yield of 67% (495 mg). Melting point: 130-131° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9a9c90681bf147f5b016f6704dfbcd29
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08624037B2
来源说明: uspto-grants-2014_01

反应 SMILES

[CH2:1]([N:28]1[C:32]([CH3:34])([CH3:33])[C:31](=[O:35])[N:30]([C:36]2[CH:41]=[CH:40][C:39]([N+:42]([O-:44])=[O:43])=[C:38]([C:45](F)(F)F)[CH:37]=2)[C:29]1=[O:49])[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:10]([CH3:12])([CH3:11])[C:9](=[O:13])[N:8]([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[C:16]([C:23](F)(F)F)[CH:15]=2)[C:7]1=[O:27].CC1(C)NC(=O)N(C2C=CC([N+]([O-])=O)=C(C(F)(F)F)C=2)C1=O>>[CH2:5]([N:6]1[C:10]([CH3:12])([CH3:11])[C:9](=[O:13])[N:8]([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[C:16]([CH3:23])[CH:15]=2)[C:7]1=[O:27])[CH2:4][CH2:3][CH2:2][CH2:1][N:28]1[C:32]([CH3:34])([CH3:33])[C:31](=[O:35])[N:30]([C:36]2[CH:41]=[CH:40][C:39]([N+:42]([O-:44])=[O:43])=[C:38]([CH3:45])[CH:37]=2)[C:29]1=[O:49]